Tuberculin reaction is not attenuated in patients with rheumatoid arthritis living in a region with intermediate burden of tuberculosis
Identifieur interne : 001493 ( Main/Exploration ); précédent : 001492; suivant : 001494Tuberculin reaction is not attenuated in patients with rheumatoid arthritis living in a region with intermediate burden of tuberculosis
Auteurs : Kwang-Hoon Lee [Corée du Sud] ; Sang-Youn Jung [Corée du Sud] ; You-Jung Ha [Corée du Sud] ; Soo-Kon Lee [Corée du Sud] ; Yong-Beom Park [Corée du Sud]Source :
- Rheumatology International [ 0172-8172 ] ; 2012-05-01.
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Abstract
Abstract: Tuberculin reactions in patients with immunocompromised conditions have been reported to be attenuated compared with healthy controls. In the case of rheumatoid arthritis (RA), several studies have reported conflicting results. We performed this study to evaluate the tuberculin reaction in patients with RA in a region with intermediate burden of tuberculosis. Eighty-one RA patients and 104 age- and sex-matched controls who underwent tuberculin skin test (TST) at Severance Hospital in Seoul, South Korea were reviewed. TST was carried out using the Mantoux method. Indurations larger than 10 mm were considered positive. Information about risk factors for latent tuberculosis infection was acquired. The mean age of the patients with RA was 48 ± 14 years, and the median disease duration was 9 (1–203) months. The mean DAS28 was 5.22 ± 0.13. The control group consisted of healthy living donors for liver transplantation and the patients with diseases not related with immunosuppression. BCG vaccination, close contact history with active tuberculosis, and history of pulmonary tuberculosis were not different between the two groups. The positive rate of TST (34.6% vs. 38.5%) and the median skin induration size (5 mm vs. 6 mm) of the two groups were similar. Medications and DAS28 were not associated with the TST result. The tuberculin reaction of patients with RA is not attenuated compared with that of controls in South Korea.
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DOI: 10.1007/s00296-011-1889-8
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In the case of rheumatoid arthritis (RA), several studies have reported conflicting results. We performed this study to evaluate the tuberculin reaction in patients with RA in a region with intermediate burden of tuberculosis. Eighty-one RA patients and 104 age- and sex-matched controls who underwent tuberculin skin test (TST) at Severance Hospital in Seoul, South Korea were reviewed. TST was carried out using the Mantoux method. Indurations larger than 10 mm were considered positive. Information about risk factors for latent tuberculosis infection was acquired. The mean age of the patients with RA was 48 ± 14 years, and the median disease duration was 9 (1–203) months. The mean DAS28 was 5.22 ± 0.13. The control group consisted of healthy living donors for liver transplantation and the patients with diseases not related with immunosuppression. BCG vaccination, close contact history with active tuberculosis, and history of pulmonary tuberculosis were not different between the two groups. The positive rate of TST (34.6% vs. 38.5%) and the median skin induration size (5 mm vs. 6 mm) of the two groups were similar. Medications and DAS28 were not associated with the TST result. The tuberculin reaction of patients with RA is not attenuated compared with that of controls in South Korea.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Kwang Hoon" sort="Lee, Kwang Hoon" uniqKey="Lee K" first="Kwang-Hoon" last="Lee">Kwang-Hoon Lee</name></region><name sortKey="Ha, You Jung" sort="Ha, You Jung" uniqKey="Ha Y" first="You-Jung" last="Ha">You-Jung Ha</name><name sortKey="Jung, Sang Youn" sort="Jung, Sang Youn" uniqKey="Jung S" first="Sang-Youn" last="Jung">Sang-Youn Jung</name><name sortKey="Lee, Soo Kon" sort="Lee, Soo Kon" uniqKey="Lee S" first="Soo-Kon" last="Lee">Soo-Kon Lee</name><name sortKey="Park, Yong Beom" sort="Park, Yong Beom" uniqKey="Park Y" first="Yong-Beom" last="Park">Yong-Beom Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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